Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM337778
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
370±n/a nM
Citation
Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Tersteegen, A; Zubov, D; Kast, R; Schamberger, J; Schäfer, M Substituted uracils and use thereof US Patent US9751843 Publication Date 9/5/2017
More Info.:
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
Inhibitor
Name:
BDBM337778
Synonyms:
3-[2-Chloro-3-(trifluoromethyl)benzyl]-1-[4-(3-methyl-2-oxoimidazolidin-1-yl)phenyl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid | US9751843, 171
Type:
Small organic molecule
Emp. Form.:
C23H18ClF3N4O5
Mol. Mass.:
522.861
SMILES:
CN1CCN(C1=O)c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O