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Target
Chymase
Ligand
BDBM337796
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
13.0±n/a nM
Citation
 Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Tersteegen, A; Zubov, D; Kast, R; Schamberger, J; Schäfer, M Substituted uracils and use thereof US Patent  US9751843 Publication Date 9/5/2017 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM337796
Synonyms:
1-[2-Fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-2,4-dioxo-3-[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (R enantiomer) | US9751843, 190
Type:
Small organic molecule
Emp. Form.:
C24H17F4N3O6
Mol. Mass.:
519.4019
SMILES:
OC(=O)c1cn(-c2ccc(cc2F)N2CCOC2=O)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O |r|
Structure:
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