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Target
Nuclear receptor ROR-gamma
Ligand
BDBM338349
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
320±n/a nM
Citation
 Fauber, B; Gobbi, A; Rene, O; van Niel, MB; Gancia, E; Gaines, S; Ladduwahetty, T; Vesey, D; Ward, S; Winship, P Aryl sultam derivatives as RORc modulators US Patent  US9751873 Publication Date 9/5/2017 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM338349
Synonyms:
(1R,5S,8R)-3-[3-Fluoro-4-((3S,6S)- 3-methyl-1,1-dioxo-6-phenyl- [1,2]thiazinan-2-ylmethyl)-phenyl]- 8-[1,2,4]triazol-4-yl-3-aza- bicyclo[3.2.1]octane | US9751873, Example 36
Type:
Small organic molecule
Emp. Form.:
C27H32FN5O2S
Mol. Mass.:
509.639
SMILES:
C[C@H]1CC[C@@H](c2ccccc2)S(=O)(=O)N1Cc1ccc(cc1F)N1C[C@@H]2CC[C@H](C1)[C@@H]2n1cnnc1 |r|
Structure:
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