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Target
Nuclear receptor ROR-gamma
Ligand
BDBM338408
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
264±n/a nM
Citation
 Fauber, B; Gobbi, A; Rene, O; van Niel, MB; Gancia, E; Gaines, S; Ladduwahetty, T; Vesey, D; Ward, S; Winship, P Aryl sultam derivatives as RORc modulators US Patent  US9751873 Publication Date 9/5/2017 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM338408
Synonyms:
4-[4-[3-fluoro-4-[[(3S,6R)-3-methyl- 1,1-dioxo-6-phenyl-thiazinan-2- yl]methyl]phenyl]piperazin-1-yl]-2- hydroxy-benzoic acid | US9751873, Example 96
Type:
Small organic molecule
Emp. Form.:
C29H32FN3O5S
Mol. Mass.:
553.645
SMILES:
C[C@H]1CCC(c2ccccc2)S(=O)(=O)N1Cc1ccc(cc1F)N1CCN(CC1)c1ccc(C(O)=O)c(O)c1 |r|
Structure:
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