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Target
Nuclear receptor ROR-gamma
Ligand
BDBM338473
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
1000±n/a nM
Citation
 Fauber, B; Gobbi, A; Rene, O; van Niel, MB; Gancia, E; Gaines, S; Ladduwahetty, T; Vesey, D; Ward, S; Winship, P Aryl sultam derivatives as RORc modulators US Patent  US9751873 Publication Date 9/5/2017 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM338473
Synonyms:
2-[2,5-difluoro-4-[[(3S,6R)-3- methyl-1,1-dioxo-6-phenyl- thiazinan-2-yl]methyl]phenyl]-N- (3-hydroxycyclobutyl)acetamide | US9751873, Example 160
Type:
Small organic molecule
Emp. Form.:
C24H28F2N2O4S
Mol. Mass.:
478.552
SMILES:
C[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1cc(F)c(CC(=O)N[C@@H]2C[C@H](O)C2)cc1F |r,wU:4.4,25.26,27.29,wD:1.0,(2.28,-1.93,;3.61,-1.15,;4.94,-1.92,;6.28,-1.15,;6.28,.38,;7.61,1.15,;8.95,.38,;10.28,1.15,;10.28,2.69,;8.95,3.46,;7.61,2.69,;4.94,1.15,;4.17,2.49,;5.71,2.49,;3.61,.38,;2.28,1.15,;.94,.38,;.94,-1.16,;-.39,-1.92,;-.39,-3.46,;-1.72,-1.16,;-3.06,-1.93,;-4.39,-1.16,;-4.39,.38,;-5.73,-1.92,;-7.06,-1.15,;-7.46,.33,;-8.95,-.07,;-10.28,.7,;-8.55,-1.55,;-1.72,.38,;-.39,1.15,;-.39,2.69,)|
Structure:
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