Target
Dimer of Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,I573V,L579M]
Ligand
BDBM518
Substrate
HIV Protease Chromogenic Peptide Substrate
Meas. Tech.
Protease Inhibition Assay
Ki
1259±n/a nM
Citation
 Clemente, JCMoose, REHemrajani, RWhitford, LRGovindasamy, LReutzel, RMcKenna, RAgbandje-McKenna, MGoodenow, MMDunn, BM Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease. Biochemistry 43:12141-51 (2004) [PubMed]  Article 
Target
Name:
Dimer of Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,I573V,L579M]
Synonyms:
HIV-1 Protease Mutant V6(54/84) | HIV-1 protease mutant (K20R V32I L33F M36I I54V L63P A71V V82A I84V L90M)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
The post-ritonavir therapy protease variant plus I54V/I84V mutations, which were created by site-directed mutagenesis.
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,I573V,L579M]
Synonyms:
HIV-1 Protease Mutant V6(54/84) chain A | HIV-1 Protease Mutant V6(54/84) chain B | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10813.12
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,I573V,L579M]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLREALLDTGADDTIFEEISLPGRWKPKMIGGIGGFVKVRQYDQIPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF
  
Component 2
Name:
Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,I573V,L579M]
Synonyms:
HIV-1 Protease Mutant V6(54/84) chain A | HIV-1 Protease Mutant V6(54/84) chain B | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10813.12
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,I573V,L579M]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLREALLDTGADDTIFEEISLPGRWKPKMIGGIGGFVKVRQYDQIPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF
  
Inhibitor
Name:
BDBM518
Synonyms:
(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]-4-(phenylsulfanyl)butyl]-decahydroisoquinoline-3-carboxamide | AG-1343 | CHEMBL584 | Nelfinavir | Viracept
Type:
Small organic molecule
Emp. Form.:
C32H45N3O4S
Mol. Mass.:
567.782
SMILES:
Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C |@@:23|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
HIV Protease Chromogenic Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1420.11
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
KARVLNPHEANLG