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Target
Tyrosine-protein phosphatase non-receptor type 1 [1-298]
Ligand
BDBM13992
Substrate
BDBM13466
Meas. Tech.
PTP1B and TCPTP Inhibition Assay
pH
7.5±n/a
Temperature
295.15±n/a K
Ki
122000±n/a nM
Citation
 Zhao, H; Liu, G; Xin, Z; Serby, MD; Pei, Z; Szczepankiewicz, BG; Hajduk, PJ; Abad-Zapatero, C; Hutchins, CW; Lubben, TH; Ballaron, SJ; Haasch, DL; Kaszubska, W; Rondinone, CM; Trevillyan, JM; Jirousek, MR Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors. Bioorg Med Chem Lett 14:5543-6 (2004) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1 [1-298]
Synonyms:
PTN1_HUMAN | PTP-1B | PTP1B | PTPN1 | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase, non-receptor type 1
Type:
Enzyme
Mol. Mass.:
34670.65
Organism:
Homo sapiens (Human)
Description:
The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli.
Residue:
298
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
  
Inhibitor
Name:
BDBM13992
Synonyms:
5-(3-{2-hydroxy-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]propyl}phenyl)-1,2-oxazole-3-carboxylic acid | Isoxazole carboxylic acid analog 3
Type:
Small organic molecule
Emp. Form.:
C21H19NO8
Mol. Mass.:
413.3775
SMILES:
COC(=O)c1c(O)cccc1OCC(O)Cc1cccc(c1)-c1cc(no1)C(O)=O
Structure:
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Substrate
Name:
BDBM13466
Synonyms:
4-Nitrophenyl phosphate disodium salt hexahydrate | 4-nitrophenyl phosphate (pNPP) | disodium (4-nitrophenyl) phosphate | para-nitrophenyl phosphate (pNPP)
Type:
Small organic molecule
Emp. Form.:
C6H4NO6P
Mol. Mass.:
217.0739
SMILES:
[O-][N+](=O)c1ccc(O[P+]([O-])([O-])[O-])cc1
Structure:
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