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TargetIDH2(R140Q)
LigandBDBM339663
Substrate/Competitorn/a
Meas. Tech.IDH2 Enzymatic Assay
IC50 550±n/a nM
Citation Popovici-Muller, JSalituro, FGSaunders, JOTravins, JYan, S Therapeutic compounds and compositions US Patent US10202339 Publication Date 2/12/2019
More Info.:Get all data from this article,  Assay Method
 
IDH2(R140Q)
Name:IDH2(R140Q)
Synonyms:idh2 r140q
Type:Enzyme Catalytic Domain
Mol. Mass.:50823.17
Organism:Homo sapiens (Human)
Description:n/a
Residue:452
Sequence:
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIGNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM339663
NameBDBM339663
Synonyms:US10202339, Compound 108
TypeSmall organic molecule
Emp. Form.C23H18F3N3O3S
Mol. Mass.473.468
SMILESFC(F)(F)CNS(=O)(=O)c1ccc(c(NC(=O)n2ccc3ccccc23)c1)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a