Reaction Details
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Report a problem with these dataTarget
Isocitrate dehydrogenase [NADP], mitochondrial [R140Q]
Ligand
BDBM339718
Substrate
n/a
Meas. Tech.
IDH2 Enzymatic Assay
IC50
550±n/a nM
Citation
Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S Therapeutic compounds and compositions US Patent US10202339 Publication Date 2/12/2019 More Info.:
Target
Name:
Isocitrate dehydrogenase [NADP], mitochondrial [R140Q]
Synonyms:
IDH2 | IDH2(R140Q) | IDHP_HUMAN | idh2 r140q
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50823.17
Organism:
Homo sapiens (Human)
Description:
P48735 (R140Q)
Residue:
452
Sequence:
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIGNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
Inhibitor
Name:
BDBM339718
Synonyms:
US10202339, Compound 163
Type:
Small organic molecule
Emp. Form.:
C22H26ClN3O4S
Mol. Mass.:
463.978
SMILES:
Clc1cccc(NC(=O)Nc2cc(ccc2C2CCCCO2)S(=O)(=O)NCC2CC2)c1
Structure:
