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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM202472
Substrate
n/a
Meas. Tech.
cAMP Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
352±n/a nM
Comments
extracted
Citation
 Ngo, VX; Old, DW; Burk, RM 15-aryl prostaglandins as EP4 agonists, and methods of use thereof US Patent  US9540357 Publication Date 1/10/2017 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM202472
Synonyms:
US9540357, example 34 | US9540357, example 35
Type:
Small organic molecule
Emp. Form.:
C30H29ClFNO4
Mol. Mass.:
522.007
SMILES:
Cc1cc(Cl)ccc1-c1cc(F)cc(c1)C(O)\C=C\[C@H]1CCC(=O)N1CCCc1ccc(cc1)C(O)=O |r|
Structure:
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