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Target
Alpha-2A adrenergic receptor [16-465]
Ligand
BDBM13017
Substrate
BDBM14062
Meas. Tech.
alpha-Adrenoceptor Radioligand Binding Assay
pH
7.7±n/a
Temperature
298.15±n/a K
Ki
100000±20000 nM
Citation
 McMillan, FM; Archbold, J; McLeish, MJ; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase. J Med Chem 47:37-44 (2004) [PubMed]  Article 
Target
Name:
Alpha-2A adrenergic receptor [16-465]
Synonyms:
ADA2A_RAT | Adra2a | Adrenaline 2 | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha2 Adrenoreceptor | CA2-47 | adrenergic Alpha2A
Type:
G-protein coupled receptor
Mol. Mass.:
48961.69
Organism:
Rattus norvegicus (rat)
Description:
P22909[16-465]
Residue:
450
Sequence:
MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
  
Inhibitor
Name:
BDBM13017
Synonyms:
1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHEMBL26717 | SKF 29661
Type:
Small organic molecule
Emp. Form.:
C9H12N2O2S
Mol. Mass.:
212.269
SMILES:
NS(=O)(=O)c1ccc2CCNCc2c1
Structure:
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Substrate
Name:
BDBM14062
Synonyms:
Clonidine | N-(2,6-dichlorophenyl)imidazolidin-2-imine | [3H]clonidine
Type:
Small organic molecule
Emp. Form.:
C9H9Cl2N3
Mol. Mass.:
230.094
SMILES:
Clc1cccc(Cl)c1\[#7]=[#6]-1/[#7]-[#6]-[#6]-[#7]-1
Structure:
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