Reaction Details Report a problem with these data
Target
Alpha-2A adrenergic receptor [16-465]
Ligand
BDBM14061
Substrate
BDBM14062
Meas. Tech.
alpha-Adrenoceptor Radioligand Binding Assay
pH
7.7±n/a
Temperature
298.15±n/a K
Ki
4500±300 nM
Citation
McMillan, FM; Archbold, J; McLeish, MJ; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase. J Med Chem 47:37-44 (2004) [PubMed] Article
More Info.:
Target
Name:
Alpha-2A adrenergic receptor [16-465]
Synonyms:
ADA2A_RAT | Adra2a | Adrenaline 2 | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha2 Adrenoreceptor | CA2-47 | adrenergic Alpha2A
Type:
G-protein coupled receptor
Mol. Mass.:
48961.69
Organism:
Rattus norvegicus (rat)
Description:
P22909[16-465]
Residue:
450
Sequence:
MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
Inhibitor
Name:
BDBM14061
Synonyms:
8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine | CHEMBL38681 | LY134046 | tetrahydrobenzazepine (THBA) deriv.
Type:
Small organic molecule
Emp. Form.:
C10H11Cl2N
Mol. Mass.:
216.107
SMILES:
Clc1ccc2CCCNCc2c1Cl