Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM174772
Substrate
n/a
Meas. Tech.
Ca2+ Flux Assay
pH
7.4±n/a
Ki
4.00±n/a nM
IC50
8.10±n/a nM
Comments
extracted
Citation
 Letavic, MA; Rudolph, DA P2X7 modulators US Patent  US9540388 Publication Date 1/10/2017 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor
Type:
Protein
Mol. Mass.:
68403.50
Organism:
Rattus norvegicus (Rat)
Description:
Q64663
Residue:
595
Sequence:
MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISSVHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCPEYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPALLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGENFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYKENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYASTCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKSLQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCGNCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEAINSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
  
Inhibitor
Name:
BDBM174772
Synonyms:
US10053462, 3 | US9102686, 3 | US9540388, 3
Type:
Small organic molecule
Emp. Form.:
C20H16ClF3N6O
Mol. Mass.:
448.829
SMILES:
FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ncccn4)n2C3)c1Cl |r,THB:9:11:17.27.28:13.15.14|
Structure:
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