Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM174810
Substrate
n/a
Meas. Tech.
Ca2+ Flux Assay
pH
7.4±n/a
Ki
7.90±n/a nM
IC50
1585±n/a nM
Comments
extracted
Citation
 Letavic, MA; Rudolph, DA P2X7 modulators US Patent  US9540388 Publication Date 1/10/2017 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor
Type:
Protein
Mol. Mass.:
68403.50
Organism:
Rattus norvegicus (Rat)
Description:
Q64663
Residue:
595
Sequence:
MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISSVHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCPEYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPALLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGENFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYKENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYASTCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKSLQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCGNCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEAINSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
  
Inhibitor
Name:
BDBM174810
Synonyms:
US10053462, 41 | US9102686, 41 | US9540388, 41
Type:
Small organic molecule
Emp. Form.:
C20H15ClF3N5O
Mol. Mass.:
433.814
SMILES:
FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl |r,THB:9:11:16.26.27:13.14|
Structure:
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