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TargetCoagulation factor XI
LigandBDBM339912
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 72.0±n/a nM
Citation Ikuma, YFukuda, NIwata, MKimura, HSuzuki, K 1-(cycloalkyl-carbonyl)proline derivative US Patent US9758480 Publication Date 9/12/2017
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor XI
Name:Coagulation factor XI
Synonyms:Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent
Type:Enzyme
Mol. Mass.:70130.58
Organism:Homo sapiens (Human)
Description:P03951
Residue:625
Sequence:
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
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  Blast E-value cutoff:
BDBM339912
NameBDBM339912
Synonyms:US9758480, 138
TypeSmall organic molecule
Emp. Form.C28H39ClFN5O4
Mol. Mass.564.092
SMILESN[C@H](CF)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@H]([C@H]1C(=O)NC1=CN2C(Cl)C(N=C2C=C1)C(O)=O)C1CCCCC1 |r,wU:16.18,15.36,7.10,1.0,wD:4.3,c:28,31,t:22,(-11.29,-28.71,;-9.96,-29.48,;-9.96,-31.02,;-11.29,-31.79,;-8.62,-28.71,;-7.29,-29.48,;-5.96,-28.71,;-5.96,-27.17,;-7.29,-26.4,;-8.62,-27.17,;-4.62,-26.4,;-3.29,-27.17,;-4.62,-24.86,;-5.87,-23.95,;-5.39,-22.49,;-3.85,-22.49,;-3.38,-23.95,;-2.04,-24.72,;-2.04,-26.26,;-.71,-23.95,;.62,-24.72,;1.96,-23.95,;3.29,-24.72,;4.75,-24.25,;5.23,-22.78,;5.66,-25.49,;4.75,-26.74,;3.29,-26.26,;1.96,-27.03,;.62,-26.26,;7.2,-25.49,;7.97,-26.82,;7.97,-24.16,;-2.77,-21.4,;-3.16,-19.91,;-2.07,-18.82,;-.59,-19.22,;-.19,-20.71,;-1.28,-21.8,)|
Structure
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