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TargetCoagulation factor XI
LigandBDBM339917
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 76.0±n/a nM
Citation Ikuma, YFukuda, NIwata, MKimura, HSuzuki, K 1-(cycloalkyl-carbonyl)proline derivative US Patent US9758480 Publication Date 9/12/2017
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor XI
Name:Coagulation factor XI
Synonyms:Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent
Type:Enzyme
Mol. Mass.:70130.58
Organism:Homo sapiens (Human)
Description:P03951
Residue:625
Sequence:
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
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BDBM339917
NameBDBM339917
Synonyms:US9758480, 170
TypeSmall organic molecule
Emp. Form.C29H33FN4O4
Mol. Mass.520.5951
SMILESN[C@H](CF)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@H]([C@H]1C(=O)Nc1ccc2[nH]c(cc2c1)C(O)=O)c1ccccc1 |r,wU:7.10,16.18,1.0,wD:15.35,4.3,(-.96,-15.03,;.37,-15.8,;.37,-17.34,;-.96,-18.11,;1.71,-15.03,;3.04,-15.8,;4.37,-15.03,;4.37,-13.49,;3.04,-12.72,;1.71,-13.49,;5.71,-12.72,;7.04,-13.49,;5.71,-11.18,;4.46,-10.27,;4.94,-8.81,;6.48,-8.81,;6.95,-10.27,;8.29,-11.04,;8.29,-12.58,;9.62,-10.27,;10.95,-11.04,;10.95,-12.58,;12.29,-13.35,;13.62,-12.58,;15.09,-13.06,;15.99,-11.81,;15.09,-10.57,;13.62,-11.04,;12.29,-10.27,;17.53,-11.81,;18.3,-13.15,;18.3,-10.48,;7.25,-7.47,;8.79,-7.47,;9.56,-6.14,;8.79,-4.81,;7.25,-4.81,;6.48,-6.14,)|
Structure
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