Reaction Details Report a problem with these data
Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM339943
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
650±n/a nM
Citation
 Crosignani, S; Cauwenberghs, S; Driessens, G; Deroose, F 3-(indol-3-yl)-pyridine derivatives, pharmaceutical compositions and methods for use US Patent  US9758505 Publication Date 9/12/2017 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:
PROTEIN
Mol. Mass.:
47874.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_825691
Residue:
406
Sequence:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
  
Inhibitor
Name:
BDBM339943
Synonyms:
2-amino-1-(4-(5-(6-fluoro-1H- indol-3-yl)pyridin-2- yl)piperazin-1-yl)ethanone | US9758505, 11
Type:
Small organic molecule
Emp. Form.:
C19H20FN5O
Mol. Mass.:
353.3934
SMILES:
NCC(=O)N1CCN(CC1)c1ccc(cn1)-c1c[nH]c2cc(F)ccc12
Structure:
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