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TargetFactor D
LigandBDBM340226
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50>10000±n/a nM
Citation Wiles, JAPhadke, ASWang, XChen, DHashimoto, AGadhachanda, VRPais, GWang, QAgarwal, ADeshpande, M Compounds for treatment of complement mediated disorders US Patent US9758537 Publication Date 9/12/2017
More Info.:Get all data from this article,  Assay Method
 
Factor D
Name:Complement factor D
Synonyms:Adipsin | C3 convertase activator | CFD | Complement Factor D | DF | PFD | Properdin factor D
Type:Protein
Mol. Mass.:27039.19
Organism:Homo sapiens (Human)
Description:P00746
Residue:253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM340226
NameBDBM340226
Synonyms:(2S,4R)-1-(2-(3-acetyl- 1H-indol-1-yl)acetyl)- N-(3-chloro-2- fluorobenzyl)-4-(7- methoxy-2- phenylquinolin-4- yloxy)pyrrolidine-2- carboxamide | US9758537, Compound 29
TypeSmall organic molecule
Emp. Form.C40H34ClFN4O5
Mol. Mass.705.173
SMILESCOc1ccc2c(O[C@@H]3C[C@H](N(C3)C(=O)Cn3cc(C(C)=O)c4ccccc34)C(=O)NCc3cccc(Cl)c3F)cc(nc2c1)-c1ccccc1 |r|
Structure
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