Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetFactor D
LigandBDBM340231
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50>10000±n/a nM
Citation Wiles, JAPhadke, ASWang, XChen, DHashimoto, AGadhachanda, VRPais, GWang, QAgarwal, ADeshpande, M Compounds for treatment of complement mediated disorders US Patent US9758537 Publication Date 9/12/2017
More Info.:Get all data from this article,  Assay Method
 
Factor D
Name:Complement factor D
Synonyms:Adipsin | C3 convertase activator | CFD | Complement Factor D | DF | PFD | Properdin factor D
Type:Protein
Mol. Mass.:27039.19
Organism:Homo sapiens (Human)
Description:P00746
Residue:253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM340231
NameBDBM340231
Synonyms:(2S,4R)-1-(2-(3-acetyl- 1H-indol-1-yl)acetyl)- N-(3-chloro-2- fluorobenzyl)-4-fluoro- N-methylpyrrolidine-2- carboxamide | US9758537, Compound 34
TypeSmall organic molecule
Emp. Form.C25H24ClF2N3O3
Mol. Mass.487.926
SMILESCN(Cc1cccc(Cl)c1F)C(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(C(C)=O)c2ccccc12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a