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TargetFactor D
LigandBDBM340232
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50<1000±n/a nM
Citation Wiles, JAPhadke, ASWang, XChen, DHashimoto, AGadhachanda, VRPais, GWang, QAgarwal, ADeshpande, M Compounds for treatment of complement mediated disorders US Patent US9758537 Publication Date 9/12/2017
More Info.:Get all data from this article,  Assay Method
 
Factor D
Name:Complement factor D
Synonyms:Adipsin | C3 convertase activator | CFD | Complement Factor D | DF | PFD | Properdin factor D
Type:Protein
Mol. Mass.:27039.19
Organism:Homo sapiens (Human)
Description:P00746
Residue:253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM340232
NameBDBM340232
Synonyms:(2S,3aS,7aS)-1-(2-(3- acetyl-6-hydroxy-1H- indol-1-yl)acetyl)-N-(3- chloro-2- fluorobenzyl)octahydro- 1H-indole-2- carboxamide | US9758537, Compound 35
TypeSmall organic molecule
Emp. Form.C28H29ClFN3O4
Mol. Mass.525.999
SMILESCC(=O)c1cn(CC(=O)N2[C@H]3CCCC[C@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(O)ccc12 |r|
Structure
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n/a