Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM340246
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
5500±n/a nM
Citation
 Wiles, JA; Phadke, AS; Wang, X; Chen, D; Hashimoto, A; Gadhachanda, VR; Pais, G; Wang, Q; Agarwal, A; Deshpande, M Compounds for treatment of complement mediated disorders US Patent  US9758537 Publication Date 9/12/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM340246
Synonyms:
(2S,4R)-N-(3-chloro-2- fluorobenzyl)-1-(2-(1,1- dioxido-2H- benzo[e][1,2,4]thiadiazin- 3-yl)acetyl)-4- fluoropyrrolidine-2- carboxamide | US9758537, Compound 49
Type:
Small organic molecule
Emp. Form.:
C21H19ClF2N4O4S
Mol. Mass.:
496.915
SMILES:
F[C@@H]1C[C@H](N(C1)C(=O)CC1=Nc2ccccc2S(=O)(=O)N1)C(=O)NCc1cccc(Cl)c1F |r,t:10|
Structure:
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