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TargetFactor D
LigandBDBM340254
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50>10000±n/a nM
Citation Wiles, JAPhadke, ASWang, XChen, DHashimoto, AGadhachanda, VRPais, GWang, QAgarwal, ADeshpande, M Compounds for treatment of complement mediated disorders US Patent US9758537 Publication Date 9/12/2017
More Info.:Get all data from this article,  Assay Method
 
Factor D
Name:Complement factor D
Synonyms:Adipsin | C3 convertase activator | CFD | Complement Factor D | DF | PFD | Properdin factor D
Type:Protein
Mol. Mass.:27039.19
Organism:Homo sapiens (Human)
Description:P00746
Residue:253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM340254
NameBDBM340254
Synonyms:1-(2-((2S,4R)-2-(3- chloro-2- fluorobenzylcarbamoyl)- 4-fluoropyrrolidin-1- yl)-2-oxoethyl)-1H- pyrazolo[3,4-e]pyridin- 3-ylphosphonic acid | US9758537, Compound 57
TypeSmall organic molecule
Emp. Form.C20H19ClF2N5O5P
Mol. Mass.513.819
SMILESOP(O)(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cnccc12 |r|
Structure
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