Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM340255
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
5500±n/a nM
Citation
Wiles, JA; Phadke, AS; Wang, X; Chen, D; Hashimoto, A; Gadhachanda, VR; Pais, G; Wang, Q; Agarwal, A; Deshpande, M Compounds for treatment of complement mediated disorders US Patent US9758537 Publication Date 9/12/2017
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM340255
Synonyms:
(2S,4R)-1-(2-(4- acetylnaphthalen-1- yl)acetyl)-N-(3-chloro- 2-fluorobenzyl)-4- fluoropyrrolidine-2- carboxamide | US9758537, Compound 58
Type:
Small organic molecule
Emp. Form.:
C26H23ClF2N2O3
Mol. Mass.:
484.922
SMILES:
CC(=O)c1ccc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccccc12 |r|