Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM340267
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>10000±n/a nM
Citation
Wiles, JA; Phadke, AS; Wang, X; Chen, D; Hashimoto, A; Gadhachanda, VR; Pais, G; Wang, Q; Agarwal, A; Deshpande, M Compounds for treatment of complement mediated disorders US Patent US9758537 Publication Date 9/12/2017
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM340267
Synonyms:
US9758537, Compound 70 | ethyl 3-(9-(2-((2S,4R)- 2-(3-chloro-2- fluorobenzylcarbamoyl)- 4-fluoropyrrolidin-1- yl)-2-oxoethyl)-3,4- dihydro-1H-pyrido[3,4- b]indol-2(9H)-yl)-3- oxopropanoate
Type:
Small organic molecule
Emp. Form.:
C30H31ClF2N4O5
Mol. Mass.:
601.041
SMILES:
CCOC(=O)CC(=O)N1CCc2c(C1)n(CC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cccc(Cl)c1F)c1ccccc21 |r|