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TargetFactor D
LigandBDBM340297
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50<1000±n/a nM
Citation Wiles, JAPhadke, ASWang, XChen, DHashimoto, AGadhachanda, VRPais, GWang, QAgarwal, ADeshpande, M Compounds for treatment of complement mediated disorders US Patent US9758537 Publication Date 9/12/2017
More Info.:Get all data from this article,  Assay Method
 
Factor D
Name:Complement factor D
Synonyms:Adipsin | C3 convertase activator | CFD | Complement Factor D | DF | PFD | Properdin factor D
Type:Protein
Mol. Mass.:27039.19
Organism:Homo sapiens (Human)
Description:P00746
Residue:253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM340297
NameBDBM340297
Synonyms:1-(2-((1R,3S,5R)-3-(3- chloro-2- fluorobenzylcarbamoyl)- 2-azabicyclo[3.1.0]hexan- 2-yl)-2-oxoethyl)-1H- thieno[3,2-c]pyrazole-3- carboxamide | US9758537, Compound 107
TypeSmall organic molecule
Emp. Form.C21H19ClFN5O3S
Mol. Mass.475.924
SMILESNC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccsc12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a