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TargetAtaxin-1
LigandBDBM321987
Substrate/Competitorn/a
Meas. Tech.Biological Assay
IC50 289±n/a nM
Citation Beattie, DBaettig, ULegrand, DMLister, ASMcKenna, JPearce, DWSandham, DASteward, ORThomson, C Autotaxin inhibitors US Patent US9763957 Publication Date 9/19/2017
More Info.:Get all data from this article,  Assay Method
 
Ataxin-1
Name:Ataxin-1
Synonyms:n/a
Type:Protein
Mol. Mass.:86941.25
Organism:Homo sapiens (Human)
Description:n/a
Residue:815
Sequence:
MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH
GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY
AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL
LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP
PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF
VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH
VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK
PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ
HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT
QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ
SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC
CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR
HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR
KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM321987
NameBDBM321987
Synonyms:(E)-3-(4-Chloro-2-((5-methyl-2H-tetrazol-2-yl)methyl)phenyl)-1-(3-(5-methyl-1,3,4-oxadiazol-2-yl)azetidin-1-yl)prop-2-en-1-one | US10183025, Example 85 | US9763957, Example 85
TypeSmall organic molecule
Emp. Form.C18H18ClN7O2
Mol. Mass.399.834
SMILESCc1nnn(Cc2cc(Cl)ccc2\C=C\C(=O)N2CC(C2)c2nnc(C)o2)n1
Structure
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n/a