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TargetAtaxin-1
LigandBDBM322016
Substrate/Competitorn/a
Meas. Tech.Biological Assay
IC50 18.0±n/a nM
Citation Beattie, DBaettig, ULegrand, DMLister, ASMcKenna, JPearce, DWSandham, DASteward, ORThomson, C Autotaxin inhibitors US Patent US9763957 Publication Date 9/19/2017
More Info.:Get all data from this article,  Assay Method
 
Ataxin-1
Name:Ataxin-1
Synonyms:n/a
Type:Protein
Mol. Mass.:86941.25
Organism:Homo sapiens (Human)
Description:n/a
Residue:815
Sequence:
MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH
GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY
AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL
LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP
PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF
VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH
VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK
PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ
HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT
QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ
SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC
CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR
HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR
KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM322016
NameBDBM322016
Synonyms:US10183025, Example 115 | US10183025, Example 115a | US10183025, Example 115b | US9763957, Example 115b | rac-(E)-1-(3-Fluoropiperidin-1-yl)-3-(2-((5-methyl-2H-tetrazol-2-yl)methyl)-4-(trifluoromethyl)phenyl)prop-2-en-1-one
TypeSmall organic molecule
Emp. Form.C18H19F4N5O
Mol. Mass.397.37
SMILESCc1nnn(Cc2cc(ccc2\C=C\C(=O)N2CCCC(F)C2)C(F)(F)F)n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a