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TargetIndoleamine 2,3-dioxygenase
LigandBDBM340795
Substrate/Competitorn/a
Meas. Tech.IDO Kynurenine Assay
IC50 1310±n/a nM
Citation Markwalder, JASeitz, SPBalog, JAHuang, AMandal, SKWilliams, DKHart, ACInghrim, J IDO inhibitors US Patent US9765018 Publication Date 9/19/2017
More Info.:Get all data from this article,  Assay Method
 
Indoleamine 2,3-dioxygenase
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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BDBM340795
NameBDBM340795
Synonyms:4'-(2-(tert-butyl) phenoxy)-3'-(3-(2,4- dichlorophenyl)ureido)-4- methoxy-[1,1'-biphenyl]- 3-carboxylic acid | US9765018, Example 103
TypeSmall organic molecule
Emp. Form.C31H28Cl2N2O5
Mol. Mass.579.47
SMILESCOc1ccc(cc1C(O)=O)-c1ccc(Oc2ccccc2C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2Cl)c1
Structure
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n/a