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TargetIndoleamine 2,3-dioxygenase
LigandBDBM340837
Substrate/Competitorn/a
Meas. Tech.IDO Kynurenine Assay
IC50 90.0±n/a nM
Citation Markwalder, JASeitz, SPBalog, JAHuang, AMandal, SKWilliams, DKHart, ACInghrim, J IDO inhibitors US Patent US9765018 Publication Date 9/19/2017
More Info.:Get all data from this article,  Assay Method
 
Indoleamine 2,3-dioxygenase
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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BDBM340837
NameBDBM340837
Synonyms:US9765018, Example 297
TypeSmall organic molecule
Emp. Form.C36H40N6O2
Mol. Mass.588.7418
SMILESCCCOc1c(NC(=O)Nc2ccc(C)cc2)cc(cc1C(CC)CCCc1ccccc1)-c1ccccc1-c1nnn[nH]1
Structure
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n/a