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TargetIndoleamine 2,3-dioxygenase
LigandBDBM340847
Substrate/Competitorn/a
Meas. Tech.IDO Kynurenine Assay
IC50 6180±n/a nM
Citation Markwalder, JASeitz, SPBalog, JAHuang, AMandal, SKWilliams, DKHart, ACInghrim, J IDO inhibitors US Patent US9765018 Publication Date 9/19/2017
More Info.:Get all data from this article,  Assay Method
 
Indoleamine 2,3-dioxygenase
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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  Blast E-value cutoff:
BDBM340847
NameBDBM340847
Synonyms:US9765018, Example 339
TypeSmall organic molecule
Emp. Form.C25H20N4O4
Mol. Mass.440.4507
SMILESCc1ccc(NC(=O)Nc2cc(cnc2Oc2ccccc2)-c2cncc(c2)C(O)=O)cc1
Structure
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n/a