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Target
Calcium-dependent protein kinase 1
Ligand
BDBM50389694
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
54.0±n/a nM
Citation
 Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent  US9765037 Publication Date 9/19/2017 
Target
Name:
Calcium-dependent protein kinase 1
Synonyms:
Calcium-dependent protein kinase 1 (CDPK1)
Type:
Protein
Mol. Mass.:
76617.33
Organism:
Cryptosporidium parvum
Description:
Q6S4W0
Residue:
677
Sequence:
MLNIEQNADECAKRVGANMVPVLHNVTEECNIKAEEKEIVPEVEEAKSESNNCLDSDDYLEGHIYAAMCTKCAGELQQKLNPTEPYRDPKKVSGKEQISRGLIIESKSFVDANKNIKFSKRSDKNEYAGLCSSPEVTTPNGERETSTDSNIKNTESTKVSHGIFDRTCLIQEHALVNRNINDFYELNLGNLGRGSYGSVVKAIDKQSGAQRAVKIILKPKLENINRLKREILIMKRLDHPNIIKLFEVFEDTNYLYFVMEICTGGELFDRIIKRGHFSERYAAVIMRQVFSAIAYCHSNEFMHRDLKPENLLFSDSSPNSLLKVIDWGFAAKCPKTHKFTSVVGTPYYVAPEVLYGSYSKLCDLWSAGVILYILLCGYPPFHGKDNVEILRKVKIGQYSLEHNSWKYVSDSAKDLIKRLLMTDPNKRISAQDALNHPWIKSQISSPNTADATYFTNDVCNSLLARFRDFQRQSKLKKLALTCVAYHLNDADIGALQKLFSTLDRNGDGVLTINEIRSALHKIQNVSQLGDDIDNLLMELDTDGNGRIDYTEFIAASIDHKLYEQESLCKAAFKVFDLDMDGRISPQELSRVLNITFLQEAFEQSTIDSLLKEVDINQDGYIDFNEFMKMMMGDKHEQKLETKVQKIEDEGSGNKKLSKGGIISDIFGATSIFKKLNN
  
Inhibitor
Name:
BDBM50389694
Synonyms:
CHEMBL2070060 | US10544104, Compound 42 | US11247972, Compound 42 | US9765037, Compound 42
Type:
Small organic molecule
Emp. Form.:
C22H25N5O
Mol. Mass.:
375.4668
SMILES:
CCCCOc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12
Structure:
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