Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM341074
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation Assay
IC50
841±n/a nM
Citation
 Casara, P; Le Diguarher, T; Henlin, J; Starck, J; Le Tiran, A; De Nanteuil, G; Geneste, O; Davidson, JE; Murray, JB; Chen, I; Walmsley, C; Graham, CJ; Ray, S; Maddox, D; Bedford, S Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them US Patent  US9765056 Publication Date 9/19/2017 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM341074
Synonyms:
1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]-phenyl}-3-(diphenylcarbamoyl)-1H-indazole-6-carboxylic acid | US9765056, Example 133
Type:
Small organic molecule
Emp. Form.:
C38H31N5O4
Mol. Mass.:
621.6838
SMILES:
NC[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccc(cc12)C(O)=O
Structure:
Search PDB for entries with ligand similarity: