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Target
Apoptosis regulator Bcl-2
Ligand
BDBM341097
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation Assay
IC50
7.80±n/a nM
Citation
 Casara, P; Le Diguarher, T; Henlin, J; Starck, J; Le Tiran, A; De Nanteuil, G; Geneste, O; Davidson, JE; Murray, JB; Chen, I; Walmsley, C; Graham, CJ; Ray, S; Maddox, D; Bedford, S Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them US Patent  US9765056 Publication Date 9/19/2017 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM341097
Synonyms:
N-(4-Hydroxyphenyl)-1-{6-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]-2H-1,3-benzodioxol-5-yl}-N-phenyl-1H-indole-3-carboxamide dihydrochloride | US9765056, Example 164
Type:
Small organic molecule
Emp. Form.:
C44H41N5O5
Mol. Mass.:
719.8268
SMILES:
CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3ccccc23)CC1
Structure:
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