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Target
Aurora kinase A
Ligand
BDBM14194
Substrate
Histone H3
Meas. Tech.
Aurora Kinase Inhibition Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
39±n/a nM
Citation
 Moriarty, KJ; Koblish, HK; Garrabrant, T; Maisuria, J; Khalil, E; Ali, F; Petrounia, IP; Crysler, CS; Maroney, AC; Johnson, DL; Galemmo, RA The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: a new class of Aurora-A kinase inhibitors. Bioorg Med Chem Lett 16:5778-83 (2006) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AURKA_MOUSE | Aik | Airk1 | Ark1 | Aura | Aurka | Aurora Kinase A (Aurora-A) | Aurora kinase A | Aurora-family kinase 1 | Aurora/IPL1-related kinase 1 | Ayk1 | Btak | Iak1 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase Aurora-A | Serine/threonine-protein kinase Ayk1 | Stk15 | Stk6
Type:
Enzyme
Mol. Mass.:
44791.66
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
395
Sequence:
MDRCKENCVSRPVKTTVPFGPKRVLVTEQIPSQNLGSASSGQAQRVLCPSNSQRVPSQAQKLGAGQKPAPKQLPAASVPRPVSRLNNPQKNEQPAASGNDSEKEQASLQKTEDTKKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKPPTGHTSKEPTSKSS
  
Inhibitor
Name:
BDBM14194
Synonyms:
7-{bicyclo[2.2.1]heptan-2-yl}-N-[4-(4-methylpiperazin-1-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine | pyrrolopyrimidine 17
Type:
Small organic molecule
Emp. Form.:
C24H30N6
Mol. Mass.:
402.5352
SMILES:
CN1CCN(CC1)c1ccc(Nc2ncc3ccn(C4CC5CCC4C5)c3n2)cc1 |THB:18:19:25:23.22|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Histone H3
Synonyms:
H3.1-221 | H3.1-291 | H3.1-I | H31_MOUSE | H3a | H3c1 | H3g | H3h | H3i | Hist1h3a | Hist1h3g | Hist1h3h | Hist1h3i
Type:
Other Protein Type
Mol. Mass.:
15425.07
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
136
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA