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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM341426
Substrate
n/a
Meas. Tech.
Biochemical In Vitro Assay
IC50
17.0±n/a nM
Citation
 Bur, D; Grisostomi, C; Nayler, O; Remen, L; Vercauteren, M; Welford, R Tricyclic piperidine compounds US Patent  US9765092 Publication Date 9/19/2017 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM341426
Synonyms:
6-chloro-5-(2-(5-(5-cyclopropyl-3-fluoropyridin-2-yl)-2-methyl-7,8-dihydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-oxoethoxy)picolinonitrile | US9765092, Example 1.14.4
Type:
Small organic molecule
Emp. Form.:
C24H19ClFN7O2S
Mol. Mass.:
523.97
SMILES:
Cc1nn2c3C(N(CCc3nc2s1)C(=O)COc1ccc(nc1Cl)C#N)c1ncc(cc1F)C1CC1
Structure:
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