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TargetTryptophan 5-monooxygenase 1
LigandBDBM341476
Substrate/Competitorn/a
Meas. Tech.Biochemical In Vitro Assay
IC50 4.00±n/a nM
Citation Bur, DGrisostomi, CNayler, ORemen, LVercauteren, MWelford, R Tricyclic piperidine compounds US Patent US9765092 Publication Date 9/19/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Tryptophan 5-monooxygenase 1
Name:Tryptophan 5-hydroxylase_UNCURATED
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:50990.64
Organism:Homo sapiens (Human)
Description:ChEMBL_1361824
Residue:444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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  Blast E-value cutoff:
BDBM341476
NameBDBM341476
Synonyms:(R)-6-chloro-5-(2-(5-(5-(dimethylcarbamoyl)-3-fluorothiophen-2-yl)-2-methyl-7,8-dihydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-oxoethoxy)-N,N-dimethylpicolinamide | US9765092, Example 1.24.11
TypeSmall organic molecule
Emp. Form.C25H25ClFN7O4S2
Mol. Mass.606.092
SMILESCN(C)C(=O)c1cc(F)c(s1)[C@@H]1N(CCc2nc3sc(C)nn3c12)C(=O)COc1ccc(nc1Cl)C(=O)N(C)C
Structure
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n/a