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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM341539
Substrate
n/a
Meas. Tech.
Biochemical In Vitro Assay
IC50
5.00±n/a nM
Citation
 Bur, D; Grisostomi, C; Nayler, O; Remen, L; Vercauteren, M; Welford, R Tricyclic piperidine compounds US Patent  US9765092 Publication Date 9/19/2017 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM341539
Synonyms:
2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(2-methyl-5-(thiazol-5-yl)-7,8-dihydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)ethanone | US9765092, Example 1.39.3
Type:
Small organic molecule
Emp. Form.:
C22H22ClN7O3S2
Mol. Mass.:
532.038
SMILES:
Cc1nn2c3C(N(CCc3nc2s1)C(=O)COc1ccc(nc1Cl)N1CCOCC1)c1cncs1
Structure:
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