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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM341599
Substrate
n/a
Meas. Tech.
Biochemical In Vitro Assay
IC50
8.00±n/a nM
Citation
 Bur, D; Grisostomi, C; Nayler, O; Remen, L; Vercauteren, M; Welford, R Tricyclic piperidine compounds US Patent  US9765092 Publication Date 9/19/2017 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM341599
Synonyms:
1-(5-(4-chloro-2-fluorophenyl)-7,8-dihydro-[1,3,4]thia-diazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-((2-chloro-6-(oxazol-2-yl)pyridin-3-yl)oxy)ethanone | US9765092, Example 2.1.3
Type:
Small organic molecule
Emp. Form.:
C23H15Cl2FN6O3S
Mol. Mass.:
545.373
SMILES:
Fc1cc(Cl)ccc1C1N(CCc2nc3scnn3c12)C(=O)COc1ccc(nc1Cl)-c1ncco1
Structure:
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