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TargetTryptophan 5-monooxygenase 1
LigandBDBM341632
Substrate/Competitorn/a
Meas. Tech.Biochemical In Vitro Assay
IC50 4.00±n/a nM
Citation Bur, DGrisostomi, CNayler, ORemen, LVercauteren, MWelford, R Tricyclic piperidine compounds US Patent US9765092 Publication Date 9/19/2017
More Info.:Get all data from this article,  Assay Method
 
Tryptophan 5-monooxygenase 1
Name:Tryptophan 5-hydroxylase_UNCURATED
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:50990.64
Organism:Homo sapiens (Human)
Description:ChEMBL_1361824
Residue:444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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  Blast E-value cutoff:
BDBM341632
NameBDBM341632
Synonyms:1-((5R)-5-(4-chloro-2-fluorophenyl)-4a,5-dihydro-thiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(7H)-yl)-2-(2-chloro-4-morpholinophenoxy)ethanone | US9765092, Example 6.4.2
TypeSmall organic molecule
Emp. Form.C26H23Cl2FN4O3S
Mol. Mass.561.455
SMILESFc1cc(Cl)ccc1[C@@H]1C2N3C=CSC3=NC2=CCN1C(=O)COc1ccc(cc1Cl)N1CCOCC1 |c:12,16,19|
Structure
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n/a