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Target
Large neutral amino acids transporter small subunit 2
Ligand
BDBM340651
Substrate
n/a
IC50
258000±n/a nM
Citation
 Kanai, Y; Nagamori, S; Kitaura, Y; Neya, M; Matsushita, N Phenoxyalkylamine compound US Patent  US9771316 Publication Date 9/26/2017 
Target
Name:
Large neutral amino acids transporter small subunit 2
Synonyms:
LAT2 | LAT2_HUMAN | SLC7A8
Type:
Protein
Mol. Mass.:
58378.41
Organism:
Homo sapiens (Human)
Description:
Q9UHI5
Residue:
535
Sequence:
MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP
  
Inhibitor
Name:
BDBM340651
Synonyms:
US9771316, Example 53
Type:
Small organic molecule
Emp. Form.:
C16H17F4NO2S
Mol. Mass.:
363.37
SMILES:
NCCCCC(Oc1ccc(OC(F)(F)F)c(F)c1)c1cccs1
Structure:
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