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TargetNuclear receptor ROR-gamma
LigandBDBM342011
Substrate/Competitorn/a
Meas. Tech.SPA Binding Assay
IC50 39.0±n/a nM
Citation Duan, JDhar, TGJiang, BLu, ZKarmakar, AGupta, AKWeigelt, CA Carbocyclic sulfone RORγ modulators US Patent US9771320 Publication Date 9/26/2017
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor ROR-gamma
Name:Nuclear receptor ROR-gamma
Synonyms:NR1F3 | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:Protein
Mol. Mass.:58218.40
Organism:Homo sapiens (Human)
Description:P51449
Residue:518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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  Blast E-value cutoff:
BDBM342011
NameBDBM342011
Synonyms:US9771320, Example 245 | US9771320, Example 246
TypeSmall organic molecule
Emp. Form.C28H22F9NO4S
Mol. Mass.639.529
SMILESCC(=O)NC1CC(C1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 |(.51,-7.3,;-.82,-8.07,;-.82,-9.61,;-2.16,-7.3,;-2.16,-5.76,;-1.07,-4.67,;-2.16,-3.58,;-3.25,-4.67,;-1.07,-2.49,;.42,-2.89,;1.51,-1.8,;1.11,-.32,;-.38,.08,;-1.47,-1.01,;2.2,.77,;3.29,1.86,;2.89,3.35,;3.98,4.44,;3.58,5.93,;2.09,6.32,;4.67,7.01,;6.16,6.62,;6.56,5.13,;5.47,4.04,;5.87,2.55,;3.29,-.32,;4.38,-1.41,;2.2,-1.41,;4.38,.77,;1.11,1.86,;.02,2.95,;.02,.77,;2.2,2.95,;-3.25,-2.49,;-4.33,-3.58,;-2.16,-1.41,;-4.33,-1.41,;-5.82,-1.8,;-6.91,-.71,;-6.51,.77,;-7.6,1.86,;-5.02,1.17,;-3.94,.08,)|
Structure
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