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TargetNuclear receptor ROR-gamma
LigandBDBM342026
Substrate/Competitorn/a
Meas. Tech.SPA Binding Assay
IC50 43.0±n/a nM
Citation Duan, JDhar, TGJiang, BLu, ZKarmakar, AGupta, AKWeigelt, CA Carbocyclic sulfone RORγ modulators US Patent US9771320 Publication Date 9/26/2017
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor ROR-gamma
Name:Nuclear receptor ROR-gamma
Synonyms:NR1F3 | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:Protein
Mol. Mass.:58218.40
Organism:Homo sapiens (Human)
Description:P51449
Residue:518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM342026
NameBDBM342026
Synonyms:US9771320, Example 260 | US9771320, Example 261
TypeSmall organic molecule
Emp. Form.C32H28F9NO5S
Mol. Mass.709.619
SMILESFc1ccc(cc1)S(=O)(=O)C1(CC(C1)NC(=O)C1CCOCC1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F |(-6.99,2.91,;-5.9,1.82,;-6.3,.33,;-5.21,-.76,;-3.73,-.36,;-3.33,1.13,;-4.42,2.22,;-2.64,-1.45,;-3.73,-2.54,;-1.55,-.36,;-1.55,-2.54,;-.46,-3.63,;-1.55,-4.71,;-2.64,-3.63,;-1.55,-6.25,;-.21,-7.02,;1.12,-6.25,;-.21,-8.56,;1.12,-9.33,;1.12,-10.87,;-.21,-11.64,;-1.55,-10.87,;-1.55,-9.33,;-.46,-1.45,;1.03,-1.85,;2.12,-.76,;1.72,.73,;.23,1.13,;-.86,.04,;2.81,1.82,;3.9,2.91,;3.5,4.4,;4.59,5.48,;4.19,6.97,;2.7,7.37,;5.28,8.06,;6.76,7.66,;7.16,6.18,;6.07,5.09,;6.47,3.6,;1.72,2.91,;.63,4,;.63,1.82,;2.81,4,;3.9,.73,;4.99,-.36,;2.81,-.36,;4.99,1.82,)|
Structure
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