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TargetNuclear receptor ROR-gamma
LigandBDBM342071
Substrate/Competitorn/a
Meas. Tech.SPA Binding Assay
IC50 25.0±n/a nM
Citation Duan, JDhar, TGJiang, BLu, ZKarmakar, AGupta, AKWeigelt, CA Carbocyclic sulfone RORγ modulators US Patent US9771320 Publication Date 9/26/2017
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor ROR-gamma
Name:Nuclear receptor ROR-gamma
Synonyms:NR1F3 | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:Protein
Mol. Mass.:58218.40
Organism:Homo sapiens (Human)
Description:P51449
Residue:518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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  Blast E-value cutoff:
BDBM342071
NameBDBM342071
Synonyms:US9771320, Example 305
TypeSmall organic molecule
Emp. Form.C26H20F8N2O3S
Mol. Mass.592.501
SMILESFc1ccc(cc1)S(=O)(=O)[C@@]1(C[C@@H](C1)NC(=O)Cc1ccncc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F |r,wU:10.26,wD:12.15,(6.35,-3.09,;5.26,-2,;5.66,-.51,;4.57,.58,;3.09,.18,;2.69,-1.31,;3.78,-2.4,;2,1.27,;3.09,2.36,;.91,2.36,;.91,.18,;2,-.91,;.91,-2,;-.18,-.91,;.91,-3.54,;-.43,-4.31,;-1.76,-3.54,;-.43,-5.85,;-1.76,-6.62,;-1.76,-8.16,;-3.09,-8.93,;-4.43,-8.16,;-4.43,-6.62,;-3.09,-5.85,;-.18,1.27,;.22,2.76,;-.87,3.85,;-2.36,3.45,;-2.76,1.96,;-1.67,.87,;-3.45,4.54,;-4.54,5.63,;-2.36,5.63,;-1.27,6.71,;-1.27,4.54,;-3.45,6.71,;-4.54,3.45,;-5.63,2.36,;-5.63,4.54,;-3.45,2.36,)|
Structure
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