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Target
Ketohexokinase
Ligand
BDBM130600
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
>30000±n/a nM
Citation
 Zhang, X; Abad, MC; Gibbs, AC; Kuo, G; Song, F; Sui, Z; Kuo, LC Indazole compounds useful as ketohexokinase inhibitors US Patent  US9771375 Publication Date 9/26/2017 
Target
Name:
Ketohexokinase
Synonyms:
Hepatic fructokinase | KHK | KHK_HUMAN | Ketohexokinase | Ketohexokinase (KHK) | Ketohexokinase (KHK) Isoform C
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32521.64
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
298
Sequence:
MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
  
Inhibitor
Name:
BDBM130600
Synonyms:
US8822447, 79 | US9771375, Example 79
Type:
Small organic molecule
Emp. Form.:
C23H18N4O
Mol. Mass.:
366.4152
SMILES:
COc1nn(-c2ccccc2)c2cc(ccc12)-c1ccc(cc1)-n1ccnc1
Structure:
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