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TargetKetohexokinase
LigandBDBM130622
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50 1430±n/a nM
Citation Zhang, XAbad, MCGibbs, ACKuo, GSong, FSui, ZKuo, LC Indazole compounds useful as ketohexokinase inhibitors US Patent US9771375 Publication Date 9/26/2017
More Info.:Get all data from this article,  Assay Method
 
Ketohexokinase
Name:Ketohexokinase
Synonyms:Hepatic fructokinase | Ketohexokinase (KHK)
Type:Enzyme
Mol. Mass.:32521.64
Organism:Homo sapiens (Human)
Description:P50053
Residue:298
Sequence:
MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM130622
NameBDBM130622
Synonyms:US8822447, 102 | US9771375, Example 102
TypeSmall organic molecule
Emp. Form.C26H29N5O
Mol. Mass.427.5414
SMILESCCOc1cc(nc2n(nc(CC)c12)-c1ccccc1)-c1ccc(cc1)N1CCNCC1
Structure
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