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TargetKetohexokinase
LigandBDBM130645
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50>10000±n/a nM
Citation Zhang, XAbad, MCGibbs, ACKuo, GSong, FSui, ZKuo, LC Indazole compounds useful as ketohexokinase inhibitors US Patent US9771375 Publication Date 9/26/2017
More Info.:Get all data from this article,  Assay Method
 
Ketohexokinase
Name:Ketohexokinase
Synonyms:Hepatic fructokinase | Ketohexokinase (KHK)
Type:Enzyme
Mol. Mass.:32521.64
Organism:Homo sapiens (Human)
Description:P50053
Residue:298
Sequence:
MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM130645
NameBDBM130645
Synonyms:US8822447, 144 | US9771375, Example 144
TypeSmall organic molecule
Emp. Form.C21H21N5O3S
Mol. Mass.423.488
SMILESCSc1nn(-c2ccc(cc2)[N+]([O-])=O)c2cc(ccc12)C1=CCN(CC1)C(=O)CN |t:23|
Structure
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