Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase SYK
Ligand
BDBM339974
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence (HTRF) Assay
IC50
0.8±n/a nM
Citation
 Altman, MD; Cash, B; Ellis, JM; Maddess, ML; Northrup, AB; Otte, RD; Sun, B 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors US Patent  US9775839 Publication Date 10/3/2017 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM339974
Synonyms:
(S)-5-((2-aminopropyl)amino)-3-(5-bromo-1H-indol-2-yl)pyrazine-2-carboxamide | US9775839, 4.1
Type:
Small organic molecule
Emp. Form.:
C16H17BrN6O
Mol. Mass.:
389.25
SMILES:
C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(Br)ccc2[nH]1
Structure:
Search PDB for entries with ligand similarity: