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TargetTyrosine-protein kinase SYK
LigandBDBM339976
Substrate/Competitorn/a
Meas. Tech.Homogeneous Time-Resolved Fluorescence (HTRF) Assay
IC50 3.7±n/a nM
Citation Altman, MDCash, BEllis, JMMaddess, MLNorthrup, ABOtte, RDSun, B 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors US Patent US9775839 Publication Date 10/3/2017
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase SYK
Name:Tyrosine-protein kinase SYK
Synonyms:Lysyl-tRNA synthetase | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:Enzyme
Mol. Mass.:72079.99
Organism:Homo sapiens (Human)
Description:P43405
Residue:635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM339976
NameBDBM339976
Synonyms:(S)-5-((2-Aminopropyl)amino)-3-(5-(2-(2-oxopyrrolidin-1-yl)ethyl)-1H-indol-2-yl)pyrazine-2-carboxamide | US9775839, 6.1
TypeSmall organic molecule
Emp. Form.C22H27N7O2
Mol. Mass.421.4955
SMILESC[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(CCN3CCCC3=O)ccc2[nH]1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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