Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK1 [850-1154]
Ligand
BDBM349134
Substrate
n/a
Meas. Tech.
JAK1 Inhibition Assay
IC50
<100±n/a nM
Citation
Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent US10206907 Publication Date 2/19/2019
More Info.:
Target
Name:
Tyrosine-protein kinase JAK1 [850-1154]
Synonyms:
JAK1 | JAK1 (aa 850-1154) | JAK1A | JAK1B | JAK1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34949.64
Organism:
Homo sapiens (Human)
Description:
P23458[850-1154]
Residue:
305
Sequence:
EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
Inhibitor
Name:
BDBM349134
Synonyms:
Cyclobutanecarboxylic acid 4- [2-(cyclopropanecarbonyl- amino)-[1,2,4]triazolo[1,5- a]pyridin-5-yl]-benzylamide | US10206907, Compound 268
Type:
Small organic molecule
Emp. Form.:
C22H23N5O2
Mol. Mass.:
389.4503
SMILES:
O=C(Nc1nc2cccc(-c3ccc(CNC(=O)C4CCC4)cc3)n2n1)C1CC1