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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM343534
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<100±n/a nM
Citation
 Shepard, S; Shao, L; Wang, H Tricyclic heterocycles as bet protein inhibitors US Patent  US9777003 Publication Date 10/3/2017 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM343534
Synonyms:
US10442803, Example 133 | US11091484, Example 133 | US9777003, Example 133
Type:
Small organic molecule
Emp. Form.:
C24H27ClN6O
Mol. Mass.:
450.964
SMILES:
CCNC(=O)c1cc2c(ccc3nnc(C)n23)n1Cc1cc(Cl)cc(CN2CCCC2)c1
Structure:
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